An Overview of Green Synthesis and Potential Pharmaceutical
                    Applications of Nanoparticles as Targeted Drug Delivery System in
                    Biomedicines

Shweta Mittal; Chandrashekhar Mahadeo Chakole; Aman Sharma; Jaya Pandey; Meenakshi Kanwar Chauhan

doi:10.1055/a-1801-6793

Drug Research, Table of Contents

Drug Res (Stuttg) 2022; 72(05): 274-283
DOI: 10.1055/a-1801-6793

Review

An Overview of Green Synthesis and Potential Pharmaceutical Applications of Nanoparticles as Targeted Drug Delivery System in Biomedicines

Authors

Shweta Mittal

¹NDDS Research Laboratory, Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, DPSR-University, New Delhi, INDIA
Chandrashekhar Mahadeo Chakole

¹NDDS Research Laboratory, Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, DPSR-University, New Delhi, INDIA
Aman Sharma

¹NDDS Research Laboratory, Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, DPSR-University, New Delhi, INDIA
Jaya Pandey

²Amity School school of Applied Sciences Lucknow, Amity University, Uttar Pradesh, India
Meenakshi Kanwar Chauhan

¹NDDS Research Laboratory, Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, DPSR-University, New Delhi, INDIA

Abstract

Nanotechnology-based nanomedicine offers several benefits over conventional forms of therapeutic agents. Moreover, nanomedicine has become a potential candidate for targeting therapeutic agents at specific sites. However, nanomedicine prepared by synthetic methods may produce unwanted toxic effects. Due to their nanosize range, nanoparticles can easily reach the reticuloendothelial system and may produce unwanted systemic effects. The nanoparticles produced by the green chemistry approach would enhance the safety profile by avoiding synthetic agents and solvents in its preparations. This review encompasses toxicity consideration of nanoparticles, green synthesis techniques of nanoparticle preparation, biomedical application of nanoparticles, and future prospects.

Key words

green nanoparticles - nanomedicine - nanotoxicity - drug delivery

Full Text

References

References
1 Patra JK, Das G, Fraceto LF. et al. Nano based drug delivery systems: Recent developments and future prospects 10 Technology 1007 Nanotechnology 03 Chemical Sciences 0306 Physical Chemistry (incl. Structural) 03 Chemical Sciences 0303 Macromolecular and Materials Chemistry 11 Medical and He. J Nanobiotechnology 2018; 16: 1-33
2 Ventola CL. The nanomedicine revolution: part 2: current and future clinical applications. P T 2012; 37: 582-591
3 Chakole MC, Chauhan KM. Research Progress of Nanostructured Lipid Carriers in Ocular Drug Delivery. Drug Deliv Lett 2021; 11: 203-219
4 Li C, Wang J, Wang Y. et al. Recent progress in drug delivery. Acta Pharm Sin B 2019; 9: 1145-1162
5 Chauhan MK. Surface modified nanostructured lipid carrier for improved ocular delivery: in vitro and ex-vivo study. J Med Pharm allied Sci 2021; 11: 75-80
6 Din FU, Aman W, Ullah I. et al. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomedicine 2017; 12: 7291-7309
7 Khan I, Saeed K, Khan I. Nanoparticles: Properties, applications and toxicities. Arab J Chem 2019; 12: 908-931
8 Mishra M, Sharma M, Dubey R. et al. Green synthesis interventions of pharmaceutical industries for sustainable development. Curr Res Green Sustain Chem 2021; 4: 100174
9 Desai N. Challenges in development of nanoparticle-based therapeutics. AAPS J 2012; 14: 282-295
10 De Jong WH, Borm PJA. Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine 2008; 3: 133-149
11 Gupta R, Xie H. Nanoparticles in Daily Life: Applications, Toxicity and Regulations. J Environ Pathol Toxicol Oncol Off organ Int Soc Environ Toxicol Cancer 2018; 37: 209-230
12 Kamaly N, Yameen B, Wu J. et al. Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release. Chem Rev 2016; 116: 2602-2663
13 Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol 2015; 33: 941-951
14 Abdussalam-Mohammed W, Qasem Ali A, Errayes AO. Green Chemistry: Principles, Applications, and Disadvantages. Chem Methodol 2020; 4: 408-423
15 Sindhu R, Verma A, Sharma D. et al. Applications of Green Chemistry in Pharmaceutical Chemistry and Day Today Life. Arch Med Pharm Sci Res 2017; 1: 39-44
16 Kate A, Sahu LK, Pandey J. et al. Green catalysis for chemical transformation: The need for the sustainable development. Curr Res Green Sustain Chem 2022; 5: 100248
17 Duan H, Wang D, Li Y. Green chemistry for nanoparticle synthesis. Chem Soc Rev 2015; 44: 5778-5792
18 Das RK, Pachapur VL, Lonappan L. et al. Biological synthesis of metallic nanoparticles: plants, animals and microbial aspects. Nanotechnol Environ Eng 2017; 2: 1-21
19 Ovais M, Khalil AT, Islam NU. et al. Role of plant phytochemicals and microbial enzymes in biosynthesis of metallic nanoparticles. Appl Microbiol Biotechnol 2018; 102: 6799-6814
20 Mohd Yusof H, Mohamad R, Zaidan UH. et al. Microbial synthesis of zinc oxide nanoparticles and their potential application as an antimicrobial agent and a feed supplement in animal industry: a review. J Anim Sci Biotechnol 2019; 10: 57
21 Chakole CM, Sahoo PK, Pandey J. et al. A green chemistry approach towards synthesizing hydrogel for sustained ocular delivery of brinzolamide: In vitro and ex vivo evaluation. J Indian Chem Soc 2021; 100323
22 Warheit DB. Nanoparticles: Health impacts?. Mater Today 2004; 7: 32-35
23 Oberdörster G, Maynard A, Donaldson K. et al. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2005; 2: 8
24 Lanone S, Boczkowski J. Biomedical applications and potential health risks of nanomaterials: molecular mechanisms. Curr Mol Med 2006; 6: 651-663
25 Manke A, Wang L, Rojanasakul Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int 2013; 2013: 942916
26 Card JW, Zeldin DC, Bonner JC. et al. Pulmonary applications and toxicity of engineered nanoparticles. Am J Physiol Lung Cell Mol Physiol 2008; 295: L400-L411
27 Shvedova AA, Kisin ER, Mercer R. et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 2005; 289: L698-L708
28 Radomski A, Jurasz P, Alonso-Escolano D. et al. Nanoparticle-induced platelet aggregation and vascular thrombosis. Br J Pharmacol 2005; 146: 882-893
29 Dobrovolskaia MA, McNeil SE. Immunological properties of engineered nanomaterials. Nat Nanotechnol 2007; 2: 469-478
30 Nemmar A, Beegam S, Yuvaraju P. et al. Ultrasmall superparamagnetic iron oxide nanoparticles acutely promote thrombosis and cardiac oxidative stress and DNA damage in mice. Part Fibre Toxicol 2016; 13: 22
31 Li Y, Li J, Yin J. et al. Systematic influence induced by 3 nm titanium dioxide following intratracheal instillation of mice. J Nanosci Nanotechnol 2010; 10: 8544-8549
32 Kao Y-Y, Cheng T-J, Yang D-M. et al. Demonstration of an olfactory bulb-brain translocation pathway for ZnO nanoparticles in rodent cells in vitro and in vivo. J Mol Neurosci 2012; 48: 464-471
33 Asgharian B, Price OT. Deposition of ultrafine (nano) particles in the human lung. Inhal Toxicol 2007; 19: 1045-1054
34 Avila-Olias M, Pegoraro C, Battaglia G. et al. Inspired by nature: fundamentals in nanotechnology design to overcome biological barriers. Ther Deliv 2012; 4: 27-43
35 Pan Y, Neuss S, Leifert A. et al. Size-dependent cytotoxicity of gold nanoparticles. Small 2007; 3: 1941-1949
36 Choi S, Kim S, Bae Y-J. et al. Size-dependent toxicity of silver nanoparticles to Glyptotendipes tokunagai. Environ Health Toxicol 2015; 30: e2015003
37 Carlson C, Hussain SM, Schrand AM. et al. Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J Phys Chem B 2008; 112: 13608-13619
38 Lovrić J, Bazzi HS, Cuie Y. et al. Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med (Berl) 2005; 83: 377-385
39 Wang S, Lu W, Tovmachenko O. et al. Challenge in Understanding Size and Shape Dependent Toxicity of Gold Nanomaterials in Human Skin Keratinocytes. Chem Phys Lett 2008; 463: 145-149
40 Bhatia S. Natural Polymer Drug Delivery Systems Nanoparticles: Nanoparticles, Mammals and microbes. 2016
41 Cavallo D, Fanizza C, Ursini CL. et al. Multi-walled carbon nanotubes induce cytotoxicity and genotoxicity in human lung epithelial cells. J Appl Toxicol 2012; 32: 454-464
42 Chauhan VP, Popović Z, Chen O. et al. Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration. Angew Chemie Int Ed 2011; 50: 11417-11420
43 Fubini B, Fenoglio I, Tomatis M. et al. Effect of chemical composition and state of the surface on the toxic response to high aspect ratio nanomaterials. Nanomedicine 2011; 6 5: 899-920
44 Zhang Y, Xu D, Li W. et al. Effect of Size, Shape, and Surface Modification on Cytotoxicity of Gold Nanoparticles to Human HEp-2 and Canine MDCK Cells. J Nanomater 2012; 2012: 375496
45 Harris JM, Chess RB. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov 2003; 2: 214-221
46 Schellekens H, Hennink WE, Brinks V. The immunogenicity of polyethylene glycol: facts and fiction. Pharm Res 2013; 30: 1729-1734
47 Abdelghany TM, Al-Rajhi AMH, Al Abboud MA. et al. Recent Advances in Green Synthesis of Silver Nanoparticles and Their Applications: About Future Directions. A Review. Bionanoscience 2018; 8: 5-16
48 Hussain I, Singh NB, Singh A. et al. Green synthesis of nanoparticles and its potential application. Biotechnol Lett 2016; 38: 545-560
49 Shah M, Fawcett D, Sharma S. et al. Green Synthesis of Metallic Nanoparticles via Biological Entities. Mater (Basel, Switzerland) 2015; 8: 7278-7308
50 Nadaroglu H, Onem H, Alayli Gungor A. Green synthesis of Ce(2)O(3) NPs and determination of its antioxidant activity. IET nanobiotechnology 2017; 11: 411-419
51 Korbekandi H, Iravani S, Abbasi S. Production of nanoparticles using organisms. Crit Rev Biotechnol 2009; 29: 279-306
52 Nikolaos P, Louise EH. Biological Synthesis of Metallic Nanoparticles by Bacteria, Fungi and Plants. J Nanomed Nanotechnol 2014; 05
53 Schlüter M, Hentzel T, Suarez C. et al. Synthesis of novel palladium(0) nanocatalysts by microorganisms from heavy-metal-influenced high-alpine sites for dehalogenation of polychlorinated dioxins. Chemosphere 2014; 117: 462-470
54 Sintubin L, De Windt W, Dick J. et al. Lactic acid bacteria as reducing and capping agent for the fast and efficient production of silver nanoparticles. Appl Microbiol Biotechnol 2009; 84: 741-749
55 Baco-Carles V, Datas L, Tailhades P. Copper Nanoparticles Prepared from Oxalic Precursors. ISRN Nanotechnol 2011; 2011: 729594
56 Gao Y, Wei Z, Li F. et al. Synthesis of a morphology controllable Fe3O4 nanoparticle/hydrogel magnetic nanocomposite inspired by magnetotactic bacteria and its application in H2O2 detection. Green Chem 2014; 16: 1255-1261
57 Ummartyotin S, Bunnak N, Juntaro J. et al. Synthesis of colloidal silver nanoparticles for printed electronics. Comptes Rendus Chim 2012; 15: 539-544
58 Mukherjee P, Ahmad A, Mandal D. et al. Fungus-Mediated Synthesis of Silver Nanoparticles and Their Immobilization in the Mycelial Matrix: A Novel Biological Approach to Nanoparticle Synthesis. Nano Lett 2001; 1: 515-519
59 Spadaro D, Gullino ML. Improving the efficacy of biocontrol agents against soilborne pathogens. Crop Prot 2005; 24: 601-613
60 Mukherjee P, Roy M, Mandal BP. et al. Green synthesis of highly stabilized nanocrystalline silver particles by a non-pathogenic and agriculturally important fungus T. asperellum. Nanotechnology 2008; 19: 75103
61 Vahabi K, Mansoori GA, Karimi S. Biosynthesis of Silver Nanoparticles by Fungus Trichoderma Reesei (A Route for Large-Scale Production of AgNPs). Insciences J 2011; 1: 65-79
62 Mandal D, Bolander ME, Mukhopadhyay D. et al. The use of microorganisms for the formation of metal nanoparticles and their application. Appl Microbiol Biotechnol 2006; 69: 485-492
63 Hulkoti NI, Taranath TC. Biosynthesis of nanoparticles using microbes- a review. Colloids Surf B Biointerfaces 2014; 121: 474-483
64 Kowshik M, Ashtaputre S, Kharrazi S. et al. Extracellular synthesis of silver nanoparticles by a silver-tolerant yeast strain MKY3. Nanotechnology 2002; 14: 95-100
65 Gericke M, Pinches A. Microbial production of gold nanoparticles. Gold Bull 2006; 39: 22-28
66 Siddiqi KS, Husen A. Fabrication of Metal and Metal Oxide Nanoparticles by Algae and their Toxic Effects. Nanoscale Res Lett 2016; 11: 363
67 Karaduman I, Güngör AA, Nadaroglu H. et al. Green synthesis of $γ$-Fe2O3 nanoparticles for methane gas sensing. J Mater Sci Mater Electron 2017; 28: 16094-16105
68 Luangpipat T, Beattie IR, Chisti Y. et al. Gold nanoparticles produced in a microalga. J Nanoparticle Res 2011; 13: 6439-6445
69 Mittal AK, Chisti Y, Banerjee UC. Synthesis of metallic nanoparticles using plant extracts. Biotechnol Adv 2013; 31: 346-356
70 Husseiny MI, El-Aziz MA, Badr Y. et al. Biosynthesis of gold nanoparticles using Pseudomonas aeruginosa. Spectrochim Acta A Mol Biomol Spectrosc 2007; 67: 1003-1006
71 Durán N, Seabra AB. Metallic oxide nanoparticles: state of the art in biogenic syntheses and their mechanisms. Appl Microbiol Biotechnol 2012; 95: 275-288
72 Makarov VV, Love AJ, Sinitsyna OV. et al. „Green“ nanotechnologies: synthesis of metal nanoparticles using plants. Acta Naturae 2014; 6: 35-44
73 Bar H, Bhui DK, Sahoo GP. et al. Green synthesis of silver nanoparticles using latex of Jatropha curcas. Colloids Surfaces A Physicochem Eng Asp 2009; 339: 134-139
74 Krishnaraj C, Jagan EG, Rajasekar S. et al. Synthesis of silver nanoparticles using Acalypha indica leaf extracts and its antibacterial activity against water borne pathogens. Colloids Surf B Biointerfaces 2010; 76: 50-56
75 Lukman AI, Gong B, Marjo CE. et al. Facile synthesis, stabilization, and anti-bacterial performance of discrete Ag nanoparticles using Medicago sativa seed exudates. J Colloid Interface Sci 2011; 353: 433-444
76 Mallikarjuna K, Narasimha G, Dillip GR. et al. Green synthesis of silver nanoparticles using Ocimum leaf extract and their characterization. Dig J Nanomater Biostructures 2011; 6: 181-186
77 Edison TJI, Sethuraman MG. Instant green synthesis of silver nanoparticles using Terminalia chebula fruit extract and evaluation of their catalytic activity on reduction of methylene blue. Process Biochem 2012; 47: 1351-1357
78 Poinern GEJ, Chapman P, Shah M. et al. Green biosynthesis of silver nanocubes using the leaf extracts from Eucalyptus macrocarpa. Nano Bull 2013; 2: 130101
79 Das RK, Gogoi N, Bora U. Green synthesis of gold nanoparticles using Nyctanthes arbortristis flower extract. Bioprocess Biosyst Eng 2011; 34: 615-619
80 Kasthuri J, Kathiravan K, Rajendiran N. Phyllanthin-assisted biosynthesis of silver and gold nanoparticles: A novel biological approach. J Nanoparticle Res 2009; 11: 1075-1085
81 Raveendran P, Fu J, Wallen SL. Completely “Green” Synthesis and Stabilization of Metal Nanoparticles. J Am Chem Soc 2003; 125: 13940-13941
82 Ma Y, Li N, Yang C. et al. One-step synthesis of amino-dextran-protected gold and silver nanoparticles and its application in biosensors. Anal Bioanal Chem 2005; 382: 1044-1048
83 Saha S, Pal A, Kundu S. et al. Photochemical Green Synthesis of Calcium-Alginate-Stabilized Ag and Au Nanoparticles and Their Catalytic Application to 4-Nitrophenol Reduction. Langmuir 2010; 26: 2885-2893
84 Laudenslager MJ, Schiffman JD, Schauer CL. Carboxymethyl chitosan as a matrix material for platinum, gold, and silver nanoparticles. Biomacromolecules 2008; 9: 2682-2685
85 Cai J, Kimura S, Wada M. et al. Nanoporous cellulose as metal nanoparticles support. Biomacromolecules 2009; 10: 87-94
86 Kemp MM, Kumar A, Mousa S. et al. Synthesis of gold and silver nanoparticles stabilized with glycosaminoglycans having distinctive biological activities. Biomacromolecules 2009; 10: 589-595
87 Shankar SS, Rai A, Ahmad A. et al. Rapid synthesis of Au, Ag, and bimetallic Au core-Ag shell nanoparticles using Neem (Azadirachta indica) leaf broth. J Colloid Interface Sci 2004; 275: 496-502
88 Mondal S, Roy N, Laskar RA. et al. Biogenic synthesis of Ag, Au and bimetallic Au/Ag alloy nanoparticles using aqueous extract of mahogany (Swietenia mahogani JACQ.) leaves. Colloids Surf B Biointerfaces 2011; 82: 497-504
89 Sheny DS, Mathew J, Philip D. Phytosynthesis of Au, Ag and Au-Ag bimetallic nanoparticles using aqueous extract and dried leaf of Anacardium occidentale. Spectrochim Acta A Mol Biomol Spectrosc 2011; 79: 254-262
90 Iravani S. Green synthesis of metal nanoparticles using plants. Green Chem 2011; 13: 2638-2650
91 Dubey SP, Lahtinen M, Sillanpää M. Tansy fruit mediated greener synthesis of silver and gold nanoparticles. Process Biochem 2010; 45: 1065-1071
92 Sathishkumar M, Sneha K, Yun Y-S. Immobilization of silver nanoparticles synthesized using Curcuma longa tuber powder and extract on cotton cloth for bactericidal activity. Bioresour Technol 2010; 101: 7958-7965
93 Prathna TC, Chandrasekaran N, Raichur AM. et al. Kinetic evolution studies of silver nanoparticles in a bio-based green synthesis process. Colloids Surfaces A Physicochem Eng Asp 2011; 377: 212-216
94 Chandran SP, Chaudhary M, Pasricha R. et al. Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract. Biotechnol Prog 2006; 22: 577-583
95 Gholami-Shabani M, Shams-Ghahfarokhi M, Gholami-Shabani Z. et al. Enzymatic synthesis of gold nanoparticles using sulfite reductase purified from Escherichia coli: A green eco-friendly approach. Process Biochem 2015; 50: 1076-1085
96 Adelere I, Lateef A. A novel approach to the green synthesis of metallic nanoparticles: The use of agro-wastes, enzymes, and pigments. Nanotechnol Rev 2016; 5: 567-587
97 Kou J, Varma RS. Beet juice utilization: Expeditious green synthesis of noble metal nanoparticles (Ag, Au, Pt, and Pd) using microwaves. RSC Adv 2012; 2: 10283-10290
98 Nadagouda MN, Varma RS. Green and controlled synthesis of gold and platinum nanomaterials using vitamin B2: density-assisted self-assembly of nanospheres, wires and rods. Green Chem 2006; 8: 516-518
99 Shao Y, Wu C, Wu T. et al. Green synthesis of sodium alginate-silver nanoparticles and their antibacterial activity. Int J Biol Macromol 2018; 111: 1281-1292
100 Malassis L, Dreyfus R, Murphy RJ. et al. One-step green synthesis of gold and silver nanoparticles with ascorbic acid and their versatile surface post-functionalization. RSC Adv 2016; 6: 33092-33100
101 Baruwati B, Varma RS. High value products from waste: grape pomace extract – a three-in-one package for the synthesis of metal nanoparticles. ChemSusChem 2009; 2: 1041-1044
102 Cho K, Wang X, Nie S. et al. Therapeutic nanoparticles for drug delivery in cancer. Clin cancer Res an Off J Am Assoc Cancer Res 2008; 14: 1310-1316
103 Devendiran RM, Chinnaiyan Skumar, Yadav NK. et al. Green synthesis of folic acid-conjugated gold nanoparticles with pectin as reducing/stabilizing agent for cancer theranostics. RSC Adv 2016; 6: 29757-29768
104 Elia P, Zach R, Hazan S. et al. Green synthesis of gold nanoparticles using plant extracts as reducing agents. Int J Nanomedicine 2014; 9: 4007-4021
105 Valodkar M, Rathore PS, Jadeja RN. et al. Cytotoxicity evaluation and antimicrobial studies of starch capped water soluble copper nanoparticles. J Hazard Mater 2012; 201–202 244-249
106 Wang C, Mathiyalagan R, Kim YJ. et al. Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities. Int J Nanomedicine 2016; 11: 3691-3701
107 Ganeshkumar M, Ponrasu T, Raja MD. et al. Green synthesis of pullulan stabilized gold nanoparticles for cancer targeted drug delivery. Spectrochim Acta Part A Mol Biomol Spectrosc 2014; 130: 64-71
108 Patra S, Mukherjee S, Barui AK. et al. Green synthesis, characterization of gold and silver nanoparticles and their potential application for cancer therapeutics. Mater Sci Eng C 2015; 53: 298-309
109 Mukherjee S, Sau S, Madhuri D. et al. Green Synthesis and Characterization of Monodispersed Gold Nanoparticles: Toxicity Study, Delivery of Doxorubicin and Its Bio-Distribution in Mouse Model. J Biomed Nanotechnol 2016; 12: 165-181
110 Morens DM, Fauci AS. Emerging infectious diseases: threats to human health and global stability. PLoS Pathog 2013; 9: e1003467
111 Prentice CR, McNicol GP, Douglas AS. Effects on blood coagulation, fibrinolysis, and platelet aggregation of normal and atheronatous aortic tissue. J Clin Pathol 1966; 19: 154-158
112 Kim H-S, Jun SH, Koo YK. et al. Green synthesis and nanotopography of heparin-reduced gold nanoparticles with enhanced anticoagulant activity. J Nanosci Nanotechnol 2013; 13: 2068-2076
113 Bayat Tork M, Hemmati Nejad N, Ghalehbagh S. et al. In situ green synthesis of silver nanoparticles/chitosan/poly vinyl alcohol/poly ethylene glycol hydrogel nanocomposite for novel finishing of nasal tampons. J Ind Text 2014; 45: 1399-1416
114 Raveendran S, Ravindran Girija A, Balasubramanian S. et al. Green Approach for Augmenting Biocompatibility to Quantum Dots by Extremophilic Polysaccharide Conjugation and Nontoxic Bioimaging. ACS Sustain Chem Eng 2014; 2: 1551-1558
115 Processes G. Green Processes for Nanotechnology. Green Process Nanotechnol 2015;
116 Huo Q. A perspective on bioconjugated nanoparticles and quantum dots. Colloids Surf B Biointerfaces 2007; 59: 1-10
117 Sunkar S, Nachiyar CV. Biogenesis of antibacterial silver nanoparticles using the endophytic bacterium Bacillus cereus isolated from Garcinia xanthochymus. Asian Pac J Trop Biomed 2012; 2: 953-959
118 Ahmad N, Sharma S, Alam MK. et al. Rapid synthesis of silver nanoparticles using dried medicinal plant of basil. Colloids Surfaces B Biointerfaces 2010; 81: 81-86
119 Du L, Jiang H, Liu X. et al. Biosynthesis of gold nanoparticles assisted by Escherichia coli DH5α and its application on direct electrochemistry of hemoglobin. Electrochem commun 2007; 9: 1165-1170
120 Bhainsa KC, D’Souza SF. Extracellular biosynthesis of silver nanoparticles using the fungus Aspergillus fumigatus. Colloids Surfaces B Biointerfaces 2006; 47: 160-164
121 Sanghi R, Verma P. Biomimetic synthesis and characterisation of protein capped silver nanoparticles. Bioresour Technol 2009; 100: 501-504
122 Raliya R, Tarafdar JC. Biosynthesis and characterization of zinc, magnesium and titanium nanoparticles: an eco-friendly approach. Int Nano Lett 2014; 4: 93
123 Shivaji S, Madhu S, Singh S. Extracellular synthesis of antibacterial silver nanoparticles using psychrophilic bacteria. Process Biochem 2011; 46: 1800-1807
124 Kowshik M, Vogel W, Urban J. et al. Microbial Synthesis of Semiconductor PbS Nanocrystallites. Adv Mater 2002; 14: 815-818